Bioregulator Peptides
Khavinson bioregulators: Russian peptide bioregulation research. Evidence dossiers on epithalon, thymalin, cortexin, and synthetic tripeptides.
Bioregulator peptides are short peptides developed primarily by Russian scientist Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. These compounds are claimed to regulate gene expression in specific tissues through epigenetic mechanisms.
Evidence Note: Most bioregulator research originates from a single Russian institute with limited independent Western validation. Evidence quality for most compounds is very low. The 2025 UK replication of epithalon's telomerase effects was the first significant independent confirmation.
Synthetic Bioregulators
Defined amino acid sequences synthesized to mimic tissue-specific peptide signals.
Bronchogen
AEDL, Ala-Glu-Asp-Leu, Bronchial tetrapeptide +1 more
A synthetic tetrapeptide (Ala-Glu-Asp-Leu) developed by Russian scientist Vladimir Khavinson for bronchial and respiratory tissue support. Claimed to modulate bronchial epithelium gene expression and provide respiratory protective effects. No Western clinical validation; all evidence from Russian bioregulator research.
Cardiogen
AED, Ala-Glu-Asp, Cardiac tripeptide
A synthetic tripeptide (Ala-Glu-Asp) developed by Russian scientist Vladimir Khavinson for cardiac tissue support. Claimed to target cardiomyocyte gene expression and provide cardioprotective effects. No Western clinical validation exists; evidence limited to Russian preclinical and observational studies.
Chonluten
EDG-GI, Glu-Asp-Gly (GI), GI tract tripeptide +1 more
A synthetic tripeptide (Glu-Asp-Gly) developed by Vladimir Khavinson for gastrointestinal tissue support. Shares the same amino acid sequence as Kristagen but is marketed for digestive system rather than immune function. Limited to Russian studies with no Western validation or clinical trials.
Cortexin
Cortexinum, Polypeptide brain extract, Bovine brain cortex polypeptides
A Russian neuropeptide complex derived from porcine or bovine cerebral cortex, approved in Russia and CIS countries for neurological conditions. Contains low molecular weight polypeptides (1,000-10,000 Da) with proposed neurotrophic and neuroprotective properties. NOT approved by FDA, EMA, or other Western regulatory agencies. Evidence comes primarily from Russian studies with limited Western validation.
Epithalon
Epitalon, Epithalone, AGAG +1 more
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian scientist Vladimir Khavinson, claimed to activate telomerase and extend lifespan. 2025 independent Western research confirmed telomerase activation in vitro. Still not approved anywhere; no controlled human clinical trials.
Kristagen
EDG, Glu-Asp-Gly, Immune tripeptide
A synthetic tripeptide (Glu-Asp-Gly) developed by Russian scientist Vladimir Khavinson, claimed to regulate thymus function and support immune cell differentiation. No Western clinical validation exists; research is limited to Russian preclinical studies.
Livagen
KED, Lys-Glu-Asp, Hepatogen
A synthetic tripeptide (Lys-Glu-Asp) developed by Russian scientist Vladimir Khavinson, claimed to support liver function and modulate hepatic gene expression. Minimal Western validation exists; all research originates from Russian institutions with no controlled human clinical trials.
Ovagen
EDL, Glu-Asp-Leu, Hepatic tripeptide +1 more
A synthetic tripeptide (Glu-Asp-Leu) developed by Russian scientist Vladimir Khavinson for liver support. Part of the peptide bioregulation framework claiming tissue-specific gene regulation. No Western clinical validation exists.
Pancragen
KEDW, Lys-Glu-Asp-Trp, Pancreatic tetrapeptide +1 more
A synthetic tetrapeptide (Lys-Glu-Asp-Trp) developed by Russian scientist Vladimir Khavinson for pancreatic support. Claimed to modulate pancreatic tissue gene expression and support insulin-producing beta cell function. No Western clinical validation.
Pinealon
EDR, Glu-Asp-Arg, Pinealon peptide +1 more
A synthetic tripeptide (Glu-Asp-Arg) developed by Russian researcher Vladimir Khavinson as a 'peptide bioregulator' claimed to support brain function. Part of a larger Russian research program on short peptides. Evidence comes almost exclusively from Russian publications with no independent Western replication. Not approved by any Western regulatory agency.
Stamakort
Gastric peptide, Stomach bioregulator, Gastric mucosa peptide
A peptide bioregulator developed by Russian scientist Vladimir Khavinson for gastric mucosa support. Claimed to modulate stomach lining gene expression and support digestive function. No Western clinical validation exists.
Testagen
Testicular peptide, Gonad peptide, Testis bioregulator
A synthetic tripeptide developed by Russian scientist Vladimir Khavinson, claimed to support testicular tissue and modulate Leydig cell function. Proposed to influence testosterone synthesis pathways through bioregulatory mechanisms. Very limited Western validation; NOT a testosterone replacement therapy.
Thymalin
Thymulin, Thymic Factor, Timalin +1 more
A thymic peptide complex developed in Russia and used clinically in the former Soviet Union for immunomodulation. Derived from calf thymus extract, it contains multiple peptides claimed to restore immune function. Approved in Russia since the 1970s but not recognized by Western regulatory agencies. Evidence comes primarily from Russian studies with limited Western replication.
Thymogen
Glu-Trp, EW dipeptide, Timogen +2 more
A synthetic dipeptide (glutamyl-tryptophan) developed in Russia as a defined successor to thymalin. Approved in Russia for immunomodulation with extensive Russian clinical literature. Represents an attempt to create a standardized, synthetic thymic peptide. Not approved by Western regulatory agencies.
Vesugen
KED-vascular, Lys-Glu-Asp (vascular), Vascular tripeptide
A synthetic tripeptide (Lys-Glu-Asp) developed by Russian scientist Vladimir Khavinson, claimed to support vascular health by modulating endothelial gene expression. Russian studies suggest cardiovascular protective effects. No Western clinical validation or regulatory approval anywhere.
Vilon
KE, Lys-Glu, Dilysine +1 more
A synthetic dipeptide (Lys-Glu) developed by Russian scientist Vladimir Khavinson as part of the peptide bioregulation framework. Claimed to support thymus gland function and immune modulation. No Western clinical validation exists; all research originates from Russian institutes.
Tissue Extract Complexes
Peptide mixtures extracted from animal tissues rather than synthesized. These are not single defined compounds but complex mixtures.
Prostatilen
Prostate peptide extract, Samprost, Vitaprost +1 more
A peptide complex extracted from bovine prostate glands, developed in Russia and registered as a pharmaceutical for prostatitis treatment. Available as suppositories and injections in Russia and CIS countries. Has more clinical documentation than most bioregulators but lacks Western validation.
Retinalamin
Retinal peptide complex, Eye peptide, Retina bioregulator
A peptide complex extracted from bovine or porcine retinal tissue, developed by Russian scientist Vladimir Khavinson for ophthalmologic applications. Registered as a drug in Russia for retinal dystrophy and age-related macular degeneration. Very limited Western validation exists.
Cytamin Supplements
Oral peptide supplements derived from tissue extracts, marketed as dietary supplements in Russia. Cytamins contain multiple peptide fractions rather than single defined sequences. Oral bioavailability of peptides is generally very low.
Cerluten
Brain cytamin, Cerebral peptides, A-5 brain peptides
A cytamin-class peptide supplement derived from brain tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for cognitive support and neuroprotection. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Endoluten
Pineal cytamin, Pineal gland peptides, A-8 pineal peptides
A cytamin-class peptide supplement derived from pineal gland tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for pineal function and melatonin support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Sigumir
Cartilage cytamin, Joint peptides, A-6 cartilage peptides
A cytamin-class peptide supplement derived from cartilage tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for joint and cartilage support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Suprefort
Pancreatic cytamin, Pancreas peptides, A-11 pancreatic peptides
A cytamin-class peptide supplement derived from pancreatic tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for pancreatic support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Svetinorm
Liver cytamin, Hepatic peptides, A-4 liver peptides
A cytamin-class peptide supplement derived from liver tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for liver health support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Ventfort
Vascular cytamin, Blood vessel peptides, A-14 vascular peptides
A cytamin-class peptide supplement derived from blood vessel tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for vascular health support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Vladonix
Thymus cytamin, Thymic peptide supplement, A-19 thymus peptides
A cytamin-class peptide supplement derived from thymus tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for immune support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
About Bioregulator Research
The bioregulation theory proposes that short peptides (2-4 amino acids) can selectively regulate gene expression in specific tissues by interacting with DNA and chromatin. Khavinson's research claims these peptides can "normalize" tissue function and reverse age-related changes.
While intriguing, these claims require significant further validation. The proposed mechanisms—that a simple dipeptide like KE (Vilon) can selectively target thymus tissue while EDG (Kristagen) targets immune cells and the same EDG sequence in Chonluten targets the GI tract—lack a clear scientific explanation for tissue specificity.
Consumers should understand that most bioregulators have very low evidence quality, are not approved by any Western regulatory agency, and claims are based primarily on Russian research that has not been independently replicated.
Quick Reference: Bioregulator Sequences
| Name | Sequence | Target Tissue | Type |
|---|---|---|---|
| Epithalon | AEDG | Pineal gland | Tetrapeptide |
| Vilon | KE | Thymus | Dipeptide |
| Livagen | KED | Liver | Tripeptide |
| Vesugen | KED | Blood vessels | Tripeptide |
| Cardiogen | AED | Heart | Tripeptide |
| Kristagen | EDG | Immune system | Tripeptide |
| Chonluten | EDG | GI tract | Tripeptide |
| Bronchogen | AEDL | Bronchi/lungs | Tetrapeptide |
| Pinealon | EDR | Brain/pineal | Tripeptide |
| Cortexin | Complex | Brain | Extract |
| Ovagen | EDL | Liver | Tripeptide |
| Pancragen | KEDW | Pancreas | Tetrapeptide |
| Stamakort | Unknown | Stomach | Peptide |
| Vladonix | Complex | Thymus | Cytamin |
| Endoluten | Complex | Pineal gland | Cytamin |
| Cerluten | Complex | Brain | Cytamin |
| Ventfort | Complex | Blood vessels | Cytamin |
| Svetinorm | Complex | Liver | Cytamin |
| Suprefort | Complex | Pancreas | Cytamin |
| Sigumir | Complex | Cartilage | Cytamin |