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A specimen of the Longevity drawer Drawer D · Longevity

Endoluten

Research Only

A cytamin-class peptide supplement derived from pineal gland tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for pineal function and melatonin support. Contains peptide complexes rather than defined sequences. No Western clinical validation.

Pineal cytamin · Pineal gland peptides · A-8 pineal peptides

Research evidence
Low

Mostly preclinical · 1 human study

Preclinical
71%
Human research
14%

Based on 7 cited sources

Numeric assessment unreviewed

A historical numeric score is recorded but has not passed a current, compound-specific assessment review. No numeric score is displayed.

This is a limitation of the numeric assessment, not a measured absence of benefit. It does not re-review the separately recorded catalogue classification or establish efficacy or safety.

Scoring context and limitations
!
Evidence Level
low
Not FDA-approved.
Research Only
Identity
Also Known As
Pineal cytamin • Pineal gland peptides • A-8 pineal peptides

Mechanism of Action

Endoluten is a cytamin-class supplement containing peptide complexes derived from pineal gland tissue.

Cytamin Classification

Cytamins are oral supplements in the Russian bioregulator framework:

  • Tissue-derived peptide mixtures
  • Multiple peptide fractions of varying size
  • Marketed as dietary supplements
  • Not defined single compounds

Proposed Mechanisms

  1. Pineal Support - Claimed to support pineal gland function
  2. Melatonin Regulation - Proposed effects on melatonin synthesis
  3. Circadian Rhythm - Marketed for sleep and circadian support

Important Limitations

  • NOT a defined peptide - contains complex mixture
  • Oral peptide bioavailability is generally very low
  • No Western clinical validation
  • No randomized controlled trials
  • Not a substitute for melatonin supplementation
  • Not approved by any Western regulatory agency
Mechanism Pineal peptide complex supporting melatonin synthesis
Emerging 2 direct studies
Benefit may support pineal gland function
Evidence Level
Very Low
2 Animal
1 In Vitro
Mechanism Confidence
Established
Supported
Emerging
Evidence Level
High
Moderate
Low
Very Low
Synergistic
Compatible
Caution
Avoid

Both target pineal function - Epithalon is synthetic AEDG tetrapeptide, Endoluten is tissue-derived cytamin. Different administration routes and compositions.

Both target brain/pineal - Pinealon is synthetic tripeptide, Endoluten is tissue-derived complex.

Research Note: Interaction data is based on published literature, mechanistic understanding, and theoretical considerations. Most peptide combinations lack direct clinical study. This information is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare providers.

7 Sources 1 Human 5 Preclinical

Use the source links in the research discussion above to inspect the referenced records.

This dossier synthesizes available evidence from peer-reviewed literature, regulatory documents, and clinical trial registries. Evidence strength labels summarize the cited material for this entry and should be read alongside its population, model, and study limitations.

For complete methodology details, see our Methodology page.

Important Disclaimer

This dossier is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.

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3 comparisons

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