Endoluten
Research OnlyA cytamin-class peptide supplement derived from pineal gland tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for pineal function and melatonin support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Pineal cytamin · Pineal gland peptides · A-8 pineal peptides
Mostly preclinical · 1 human study
- Preclinical
- 71%
- Clinical
- 14%
Based on 7 cited sources
Demonstrated effect magnitude — not a recommendation or safety claim.
Research Depth 14 (1A~6/1B~3/1C0/1D~2/1E~3): for the oral cytamin itself there is animal-tier evidence on melatonin markers and zero attributable human studies; the rigorous Khavinson/Anisimov pineal trials used the INJECTABLE Epithalamin preparation (12374906, 11335874), so human evidence is indirect to the oral cytamin (per rule 2 not penalized on geography, only on directness/RoB). Mechanism 30 (2A10/2B~7/2C~5/2D8): target inferred (pineal/melatonin synthesis support), no binding data for the undefined mixture, but the analogous Epithalamin preparation raised melatonin in-vivo in rats and restored circadian melatonin rhythm in aged rhesus monkeys (1485734, 14743609). Plausibility 65 (3A~22/3B~20/3C~14/3D~9): the pineal->melatonin->circadian causal chain is one of the better-supported in the Khavinson program with same-class analogy from Epithalon/Epithalamin; capped by undefined composition, low oral peptide bioavailability and broad "longevity" framing. Global Coverage 27 (4A~10/4B~7/4C~10/4D0): largely one St. Petersburg group (Khavinson/Anisimov) with a semi-independent primate lab (Goncharova), ~5-20 studies across Russia and NYAS venues, no regulatory approval. Community Experience 14: dossier states no meaningful community discussion or user reports; credit only absence of an adverse signal (5D). Effectiveness not-established: no quantified human efficacy estimate for the oral cytamin and no meaningful community effect signal. Scores above cerluten (19) because the pineal->melatonin mechanism and its in-vivo replication are genuinely stronger than the brain-cytamin story.
Mechanism of Action
Endoluten is a cytamin-class supplement containing peptide complexes derived from pineal gland tissue.
Cytamin Classification
Cytamins are oral supplements in the Russian bioregulator framework:
- Tissue-derived peptide mixtures
- Multiple peptide fractions of varying size
- Marketed as dietary supplements
- Not defined single compounds
Proposed Mechanisms
- Pineal Support - Claimed to support pineal gland function
- Melatonin Regulation - Proposed effects on melatonin synthesis
- Circadian Rhythm - Marketed for sleep and circadian support
Important Limitations
- NOT a defined peptide - contains complex mixture
- Oral peptide bioavailability is generally very low
- No Western clinical validation
- No randomized controlled trials
- Not a substitute for melatonin supplementation
- Not approved by any Western regulatory agency
Epithalon
CompatibleBoth target pineal function - Epithalon is synthetic AEDG tetrapeptide, Endoluten is tissue-derived cytamin. Different administration routes and compositions.
Pinealon
CompatibleBoth target brain/pineal - Pinealon is synthetic tripeptide, Endoluten is tissue-derived complex.
Research Note: Interaction data is based on published literature, mechanistic understanding, and theoretical considerations. Most peptide combinations lack direct clinical study. This information is for educational purposes only and does not constitute medical advice. Always consult qualified healthcare providers.
Full reference list available on request. All citations link to PubMed for verification.
This dossier synthesizes available evidence from peer-reviewed literature, regulatory documents, and clinical trial registries. Evidence strength ratings follow a modified GRADE approach.
For complete methodology details, see our Methodology page.
Important Disclaimer
This dossier is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before making health decisions.
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