Longevity Peptides
Anti-aging bioregulators and longevity-focused compounds. Evidence-based dossiers on epitalon, thymalin, and related peptides.
Longevity peptides include bioregulators and compounds studied for their potential effects on aging, cellular repair, and lifespan extension. Research in this area spans from telomere biology to immune system modulation.
Endoluten
Pineal cytamin, Pineal gland peptides, A-8 pineal peptides
A cytamin-class peptide supplement derived from pineal gland tissue, part of the Russian bioregulator framework. Marketed as an oral supplement for pineal function and melatonin support. Contains peptide complexes rather than defined sequences. No Western clinical validation.
Epithalon
Epitalon, Epithalone, AGAG +1 more
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian scientist Vladimir Khavinson, claimed to activate telomerase and extend lifespan. 2025 independent Western research confirmed telomerase activation in vitro. Still not approved anywhere; no controlled human clinical trials.
FOXO4-DRI
FOXO4-D-Retro-Inverso, FOXO4-DRI Peptide, Proxofim
A D-retro-inverso peptide designed to disrupt the FOXO4-p53 interaction, selectively eliminating senescent cells (senolytic). Preclinical studies in aged mice demonstrated restored fitness, fur density, and renal function. No human clinical trials conducted. More selective than BCL-2 inhibitors but remains unproven in humans.
Glutathione
GSH, L-Glutathione, Reduced Glutathione +1 more
The master antioxidant and most abundant intracellular thiol in mammalian cells. This naturally occurring tripeptide (glutamate-cysteine-glycine) is essential for detoxification, immune function, and cellular protection. Extensively studied with strong mechanistic understanding and growing clinical evidence.
Humanin
HN, HNG, S14G-Humanin +2 more
A 24-amino acid mitochondria-derived peptide (MDP) discovered in 2001 that shows cytoprotective, anti-apoptotic, and neuroprotective effects in preclinical studies. Represents a novel class of signaling molecules encoded within mitochondrial DNA. Extensive academic research with emerging interest in aging, metabolic disease, and neurodegeneration, but no approved clinical applications.
MOTS-c
Mitochondrial ORF of the 12S rRNA type-c, Mitochondrial-derived peptide, MOTS-C peptide
A 16-amino acid mitochondrial-derived peptide encoded in mtDNA that targets AMPK/mTOR pathways for metabolic regulation. Preclinical studies show exercise mimetic and geroprotective effects. Lower MOTS-c levels found in T2D patients. No clinical trials yet conducted in humans.
SHLP-2
Small Humanin-Like Peptide 2, SHLP2, Mitochondrial-Derived Peptide 2
A 26-amino acid mitochondria-derived peptide (MDP) discovered in 2016 from the same mitochondrial DNA region as humanin. Shows cytoprotective, metabolic, and potential longevity effects in preclinical studies. Part of an emerging class of mitochondrial signaling molecules, but human therapeutic data is lacking.
SHLP-6
Small Humanin-Like Peptide 6, SHLP6, Mitochondrial-Derived Peptide 6
A 22-amino acid mitochondria-derived peptide with the unique property of being pro-apoptotic—the opposite of its sister peptides humanin and SHLP-2. Discovered in 2016, SHLP-6 may have applications in cancer and senescent cell clearance. Research is very early-stage with minimal published data.
SS-31
Elamipretide, Bendavia, MTP-131
A first-in-class mitochondria-targeting tetrapeptide that binds cardiolipin on the inner mitochondrial membrane. Developed by Stealth BioTherapeutics for mitochondrial diseases, heart failure, and age-related macular degeneration. Phase 3 trials in primary mitochondrial myopathy did not meet primary endpoints, but Barth syndrome data was positive. Strong preclinical rationale with mixed clinical translation.
About This Category
Research into peptide-mediated longevity focuses on mechanisms like telomere maintenance, immune reconstitution, and cellular repair pathways. Many bioregulators in this category originate from Russian research programs and have varying levels of Western clinical validation.