Sermorelin vs Tesamorelin
Comparison of two GHRH analogs - one discontinued (sermorelin) and one FDA-approved (tesamorelin).
Last updated: January 19, 2026
Sermorelin
Tesamorelin
Overview
Both sermorelin and tesamorelin are GHRH analogs that stimulate endogenous growth hormone release. Tesamorelin remains FDA-approved while sermorelin was discontinued.
Status Comparison
| Aspect | Sermorelin | Tesamorelin |
|---|---|---|
| FDA Status | Was approved; discontinued | Currently approved |
| Brand Name | Geref (discontinued) | Egrifta |
| Availability | Compounding only | Prescription |
Approved Indications
| Peptide | Indication | Population |
|---|---|---|
| Sermorelin | Was: Pediatric GH deficiency | Children |
| Tesamorelin | HIV lipodystrophy | Adults with HIV |
Mechanism
Both work identically:
- Bind GHRH receptors on pituitary
- Stimulate endogenous GH release
- Maintain physiologic pulsatile pattern
- Require functional pituitary
Pharmacokinetics
| Parameter | Sermorelin | Tesamorelin |
|---|---|---|
| Half-life | 10-20 min | 26-38 min |
| Administration | Daily SC | Daily SC |
| Metabolism | Proteolytic | Proteolytic |
Clinical Evidence
| Aspect | Sermorelin | Tesamorelin |
|---|---|---|
| Phase 3 Data | Yes (historical) | Yes |
| Long-term Data | Limited | Extension studies |
| VAT Reduction | Not studied | 15% reduction |
Why Sermorelin Was Discontinued
Sermorelin (Geref) was discontinued for commercial reasons, not safety or efficacy:
- Low sales volume
- Manufacturing costs
- Business decision by manufacturer
Why Choose One Over Other
| If you need… | Consider |
|---|---|
| FDA-approved option | Tesamorelin |
| HIV lipodystrophy | Tesamorelin |
| GH deficiency testing | Neither (other tests available) |
| Off-label GH stimulation | Discuss with physician |
Summary
- Tesamorelin is the only GHRH analog currently FDA-approved
- Sermorelin has historical approval but is no longer commercially available
- Both preserve physiologic GH patterns
- Tesamorelin has specific evidence for reducing visceral fat in HIV
This comparison is for educational purposes only. Tesamorelin requires a prescription and is approved for specific indications.
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Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.