Tesamorelin Safety Profile
Safety information for FDA-approved tesamorelin (Egrifta) for HIV lipodystrophy.
Last updated: January 19, 2026
For Educational Purposes Only
This safety information is compiled from clinical trial data and regulatory documents for educational purposes. It is not a substitute for professional medical advice. Always consult your healthcare provider about medication safety, especially regarding your individual circumstances, medical history, and other medications.
Safety Overview
Tesamorelin (Egrifta) is FDA-approved with established safety data from clinical trials and post-marketing experience.
Common Side Effects
| Side Effect | Frequency | Notes |
|---|---|---|
| Injection site reactions | 25-30% | Redness, itching at site |
| Arthralgia (joint pain) | 10-15% | GH-related |
| Peripheral edema | 5-10% | Fluid retention |
| Paresthesia | 5-8% | Tingling sensations |
| Hyperglycemia | 4-5% | Blood sugar effects |
Serious Warnings
Contraindications
- Active malignancy — do not use
- Disrupted hypothalamic-pituitary axis (surgery, radiation, trauma)
- Known hypersensitivity to tesamorelin or mannitol
- Pregnancy — contraindicated
Warnings and Precautions
- May worsen glucose tolerance
- Fluid retention (caution in heart/kidney disease)
- Carpal tunnel syndrome possible
- Hypersensitivity reactions reported
Monitoring Recommendations
- Blood glucose monitoring
- IGF-1 levels (periodic)
- Watch for symptoms of fluid retention
- Cancer screening as appropriate
Special Considerations
- Discontinue if malignancy develops
- Not for general anti-aging use
- Requires ongoing prescription/monitoring
This is for educational purposes. Tesamorelin is a prescription medication for specific indications.
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Important: Safety information evolves as post-marketing data accumulates. This page reflects data available as of the last update date. Check official FDA and EMA resources for the most current safety information. This content is not intended to diagnose, treat, cure, or prevent any disease.