Sermorelin Research for Body Composition
An evidence-based overview of research examining Sermorelin in the context of body composition. This page synthesizes findings from peer-reviewed literature.
Research Summary
Clinical trials have shown that GHRH therapy can improve body composition in older adults. A 20-week randomized trial in healthy older adults raised IGF-1 by 117% and reduced percent body fat by 7.4% without major adverse effects.
The 4-month GHRH analog trial by Khorram et al. showed that men experienced increased lean body mass and improved insulin sensitivity, suggesting metabolic benefits beyond simple fat loss.
Reviews of GH and IGF-1 physiology in aging note that the somatotropic decline contributes to reduced lean mass and increased body fat, providing a rationale for restoring physiologic GH pulsatility with GHRH while preserving natural feedback regulation.
Referenced Studies
Click any PMID to view the full study on PubMed.
Important Disclaimer
This page summarizes research findings and does not constitute medical advice. Sermorelin may have regulatory approval for some indications but should only be used under qualified medical supervision. Always consult a healthcare provider before making health decisions.