MK-677 Research for Muscle Wasting

In a 65-person trial of healthy older adults, fat-free mass increased without a detected strength or function gain; the trial lacked power for functional endpoints. An eight-volunteer dietary-restriction experiment measured nitrogen balance, not recovery from clinical muscle wasting. A separate 161-person hip-fracture trial raised IGF-1 without a statistically significant functional-performance benefit. These cohorts cannot establish a treatment for sarcopenia or muscle wasting.