guide
What is Semaglutide?
An introduction to semaglutide, the GLP-1 agonist behind Ozempic and Wegovy. Learn how it works, what it's approved for, and key facts about this medication.
PepCodex Research Team
6 min read
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#glp-1
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#weight-loss
#diabetes
What is Semaglutide?
Semaglutide is a medication that mimics a natural hormone called GLP-1 (glucagon-like peptide-1). It’s FDA-approved for type 2 diabetes and weight management.
Brand Names
- Ozempic — for type 2 diabetes (injection)
- Wegovy — for weight management (injection)
- Rybelsus — for type 2 diabetes (oral tablet)
How Does It Work?
Semaglutide works by:
- Increasing insulin release when blood sugar is high
- Reducing appetite through brain signaling
- Slowing stomach emptying to increase fullness
- Reducing glucagon to lower blood sugar
What Is It Used For?
Approved Uses
- Type 2 diabetes (blood sugar control)
- Chronic weight management (in obesity)
- Cardiovascular risk reduction (in obesity with heart disease)
Key Facts
| Fact | Detail |
|---|---|
| Administration | Once weekly injection or daily pill |
| Weight Loss | Average 15% in clinical trials |
| FDA Approved | Yes (2017 for diabetes, 2021 for weight) |
Common Side Effects
- Nausea (usually improves over time)
- Diarrhea or constipation
- Decreased appetite
Who Should Not Use It?
- People with personal/family history of medullary thyroid cancer
- People with Multiple Endocrine Neoplasia type 2
- Those allergic to semaglutide
This guide is for educational purposes only. Consult a healthcare provider for medical advice.
Sources & Citations
- 1
Disclaimer: This article is for educational purposes only and does not constitute medical advice. The information presented is based on current research but should not be used for diagnosis, treatment, or prevention of any disease. Always consult a qualified healthcare provider before making health decisions.