SHLP-2 vs SS-31
Comparison of SHLP-2 (Low evidence) and SS-31 (Moderate evidence).
Last updated: February 12, 2026
SHLP-2
SS-31
Overview
SHLP-2 and SS-31 are both studied in the peptide research space.
SHLP-2: A 26-amino acid mitochondria-derived peptide (MDP) discovered in 2016 from the same mitochondrial DNA region as humanin.
SS-31: A first-in-class mitochondria-targeting tetrapeptide that binds cardiolipin on the inner mitochondrial membrane.
Evidence Comparison
| Aspect | SHLP-2 | SS-31 |
|---|---|---|
| Evidence Level | Low | Moderate |
| Human Studies | 3 | 12 |
| Preclinical Studies | 17 | 23 |
| Total Sources | 20 | 35 |
Key Differences
| Aspect | SHLP-2 | SS-31 |
|---|---|---|
| Category | Longevity | Longevity |
| Evidence Strength | Low | Moderate |
| Total Sources | 20 | 35 |
| Human Studies | 3 | 12 |
Summary
- SHLP-2: Low evidence with 20 total sources (3 human)
- SS-31: Moderate evidence with 35 total sources (12 human)
This comparison is for educational purposes only and is not medical advice. Consult a healthcare professional before making any decisions about peptide use.
View Full Dossiers
Stay Updated on Peptide Comparisons
Get notified when we publish new comparison dossiers and evidence reviews.
No spam. Unsubscribe anytime.
Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.