GHRP-2 vs MK-677
Comparison of GHRP-2 (Moderate evidence) and MK-677 (Moderate evidence).
Last updated: February 12, 2026
GHRP-2
MK-677
Overview
GHRP-2 and MK-677 are both studied in the peptide research space.
GHRP-2: A synthetic hexapeptide GH secretagogue with the strongest GH-releasing potency in its class.
MK-677: An orally-active, non-peptide growth hormone secretagogue that mimics ghrelin’s effects on GHS-R1a.
Evidence Comparison
| Aspect | GHRP-2 | MK-677 |
|---|---|---|
| Evidence Level | Moderate | Moderate |
| Human Studies | 18 | 18 |
| Preclinical Studies | 19 | 12 |
| Total Sources | 52 | 42 |
Key Differences
| Aspect | GHRP-2 | MK-677 |
|---|---|---|
| Category | Hormonal | Hormonal |
| Evidence Strength | Moderate | Moderate |
| Total Sources | 52 | 42 |
| Human Studies | 18 | 18 |
Summary
- GHRP-2: Moderate evidence with 52 total sources (18 human)
- MK-677: Moderate evidence with 42 total sources (18 human)
This comparison is for educational purposes only and is not medical advice. Consult a healthcare professional before making any decisions about peptide use.
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Disclaimer: This comparison is for educational purposes only and does not constitute medical advice. Individual responses to medications vary. Always consult a qualified healthcare provider before making treatment decisions.